Tobin Bell
John Kramer / Jigsaw

Costas Mandylor
Mark Hoffman

Scott Patterson
Agent Strahm

Betsy Russell
Jill Tuck

Lyriq Bent
Rigg

Athena Karkanis
Agent Perez

Louis Ferreira
Art

Simon Reynolds
Lamanna

Donnie Wahlberg
Eric Matthews

Angus Macfadyen
Jeff Denlon

Shawnee Smith
Amanda Young

Bahar Soomekh
Lynn Denlon

Dina Meyer
Detective Allison Kerry

Mike Realba
Fisk

Marty Adams
Ivan

Sarain Boylan
Brenda

Billy Otis
Cecill

James Van Patten
Dr. Heffner / Coroner

David Boyce
Pathologist

Kevin Rushton
Trevor

Julian Richings
Vagrant

Kelly Jones
SWAT Pete

Ingrid Hart
Tracy Rigg

Niamh Wilson
Corbett Denlon

Janet Land
Morgan

Ron Lea
Rex

Joanne Boland
Crime Scene Photographer

Zoe Heath
Lab Technician

Bill Vibert
Young Cop

Eric Gores
Matt

Devon Bostick
Derek

Tony Nappo
Gus

Emmanuelle Vaugier
Addison Corday

Noam Jenkins
Michael Marks

Mike Butters
Paul Leahy

J. LaRose
Troy

Oren Koules
The Man

Alison Luther
Young Girl

Kim Roberts
Nurse Deborah

David Webster
Dr. Steve

Sandra Manson
Nurse Patti

Shauna Black
Additional Voice Talent (voice)

Darrell Dennis
Additional Voice Talent (voice)

Tracey Ferencz
Additional Voice Talent (voice)

Catherine Fitch
Additional Voice Talent (voice)

Christopher Marren
Additional Voice Talent (voice)

Christopher Morris
Additional Voice Talent (voice)

Geoffrey Pounsett
Additional Voice Talent (voice)