Frankie Muniz
Stripes (voice)

Hayden Panettiere
Channing Walsh

Bruce Greenwood
Nolan Walsh

Mandy Moore
Sandy (voice)

Wendie Malick
Clara Dalrymple

M. Emmet Walsh
Woodzie

Snoop Dogg
Lightning (voice)

Michael Clarke Duncan
Clydesdale (voice)

Jeff Foxworthy
Reggie (voice)

Whoopi Goldberg
Franny (voice)

Steve Harvey
Buzz (voice)

David Spade
Scuzz (voice)

Dustin Hoffman
Tucker (voice)

Joshua Jackson
Trenton's Pride (voice)

Joe Pantoliano
Goose (voice)

Michael Rosenbaum
Ruffshodd (voice)

Gary Bullock
John Cooper

Fred Thompson
Sir Trenton (voice)

Caspar Poyck
Mailman

Thandi Puren
Reporter

Morné Visser
Reporter

Dawn Matthews
Reporter

Matt Stern
Reporter

John Lesley
Paddock Boss

Graeme Hawkins
Track Announcer

Tarryn Meaker
Anthem Singer

Jansen Panettiere
Young Stripes (voice)

Frankie Ryan Manríquez
Young Ruffshodd (voice)

Kyle Alcazar
Young Pride (voice)

Dee Bradley Baker
Additional Voices (voice)

Bob Bergen
Additional Voices (voice)

Jess Harnell
Additional Voices (voice)