Tobey Maguire
Spider-Man / Peter Parker

Willem Dafoe
Green Goblin / Norman Osborn

Kirsten Dunst
Mary Jane Watson

James Franco
Harry Osborn

Cliff Robertson
Ben Parker

Rosemary Harris
May Parker

J.K. Simmons
J. Jonah Jameson

Joe Manganiello
Flash Thompson

Gerry Becker
Maximilian Fargas

Bill Nunn
Joseph 'Robbie' Robertson

Jack Betts
Henry Balkan

Stanley Anderson
General Slocum

Ron Perkins
Dr. Mendel Stromm

Michael Papajohn
Carjacker

K.K. Dodds
Simkins

Ted Raimi
Hoffman

Bruce Campbell
Ring Announcer

Elizabeth Banks
Miss Brant

John Paxton
Houseman

Tim DeZarn
Philip Watson

Taylor Gilbert
Madeline Watson

Randy Poffo
Bone Saw McGraw

Larry Joshua
Wrestling Promoter

Timothy Patrick Quill
Wrestling Arena Guard

Lisa Danielle
Bone-ette

Natalie T. Yeo
Bone-ette

Erica D. Porter
Bone-ette

Kristen Davidson
Bone-ette

Jason Padgett
Flash's Crony

Shan Omar Huey
Teacher

Sally Levi
Girl on Bus

Evan Arnold
Doctor

Jill Sayre
Nurse

Jim Ward
Project Coordinator

David Holcomb
Test Pilot

Octavia Spencer
Check-In Girl

Brad Grunberg
Heckler

Shane Habberstad
Little Billy

Deborah Wakeham
Billy's Mom

Rachael Bruce
Times Square Child

Mackenzie Bryce
Times Square Child

Julia Barrie
Times Square Child

Macy Gray
Macy Gray

Myk Watford
Cop at Fire

Bill Calvert
Fireman

Sylva Kelegian
Mother at Fire

Kristen Marie Holly
Young Lady at Fire

Ajay Mehta
Cabbie

Peter Appel
Cabbie

Scott Spiegel
Marine Cop

Matt Smith
Cop at Carjacking

Sara Ramirez
Cop at Carjacking

Lucy Lawless
Punk Rock Girl

Jayce Bartok
Subway Guitarist

Maribel González
Lady Dogwalker

Amy Bouril
Office Lady

Joseph D'Onofrio
Opinionated Cop

Jim Norton
Surly Truck Driver

Corey Mendell Parker
Chaperone in Tram

Ashley Edner
Girl in Tram

William Joseph Firth
Boy in Tram

Alex Black
Boy in Tram

Laura Gray
Tram Group Mother

Joe Virzi
New Yorker on Bridge

Michael Edward Thomas
New Yorker on Bridge

Jeanie Fox
New Yorker on Bridge

Robert Kerman
Tugboat Captain

Stan Lee
Man in Fair (uncredited)

Una Damon
Lab Tour Guide (uncredited)

Rick Avery
Cop (uncredited)

Peter Aylward
Colonel (uncredited)

Jillian Clare
Crying Girl in Tram (uncredited)

Chris Coppola
Kyle (uncredited)

Jesse Heiman
Spectator at School Fight (uncredited)

Leroy Patterson
World Unity Festival Attendant (uncredited)

Benny Urquidez
Mugger (uncredited)

Scott L. Schwartz
Screaming Wrestler (uncredited)

Jophery C. Brown
Chef (uncredited)

Brian J. Williams
Young Thug #2 (uncredited)

Mark De Alessandro
Cop (uncredited)

Tia Dionne Hodge
Uptown Woman (uncredited)

Loren Janes
Board of Directors Member (uncredited)

Andray Johnson
Balkan's Aide (uncredited)

Martin Pfefferkorn
Thug on 8x10 (uncredited)

Tammi Sutton
Street Vendor (uncredited)

Lindsay Thompson
Mary Jane's Friend (uncredited)

Sean Valla
Boat Light Man (uncredited)

Pete Macnamara
Pentagon Officer (uncredited)

Al Goto
Cop (uncredited)

Joni Avery
Cop (uncredited)

Sam Raimi
Popcorn Thrower (uncredited)

Craig 'Radio Man' Castaldo
Man with Bike (uncredited)

Lou Torres
Enrique