Charles Bronson
Joe Valachi

Lino Ventura
Vito Genovese

Jill Ireland
Maria Reina Valachi

Walter Chiari
Dominick Petrilli, aka "Gap"

Joseph Wiseman
Salvatore Maranzano

Gerald S. O'Loughlin
Ryan, federal agent

Amedeo Nazzari
Gaetano Reina

Fausto Tozzi
Albert Anastasia

Pupella Maggio
Letizia Reina

Angelo Infanti
Lucky Luciano

Guido Leontini
Tony Bender

María Baxa
Donna Petrillo

Mario Pilar
Salierno

Franco Borelli
Buster

Alessandro Sperli
Giuseppe 'Joe the Boss' Masseria

Natasha Chevelev
Jane

Anthony Dawson
Federal Investigator

Fred Valleca
Buck

John Alarimo
Steven Ferrigno (uncredited)

Calogero Azzaretto
Man of the clan (uncredited)

Joe Don Baker
Irish member of Valachi gang (uncredited)

Steve Belloise
Winnie (uncredited)

Angelo Boscariol
Gangster (uncredited)

Nestore Cavaricci
Prisoner with Valachi (uncredited)

Giacomo De Michelis
Augie (uncredited)

Bruno Di Luia
Luciano's Henchman (uncredited)

Arny Freeman
Warden (uncredited)

Alfonso Giganti
Wedding party guest (uncredited)

Ron Gilbert
Prison Guard (uncredited)

Frank Gio
Frank (uncredited)

Syl Lamont
Commander of Fort Monmouth (uncredited)

Imelde Marani
Donna Petrillo's friend (uncredited)

Isabelle Marchall
Mary-Lou (uncredited)

Jason McCallum
Donald Valachi (uncredited)

Sabine Sun
Jane (uncredited)

Robert Trout
Self (uncredited)

Franco Ressel
(uncredited)

Richard Dunne
Judge (uncredited)