Eddie Murphy
Axel Foley

Judge Reinhold
Billy Rosewood

Héctor Elizondo
Jon Flint

Timothy Carhart
Ellis DeWald

John Saxon
Orrin Sanderson

Jon Tenney
Levine

Joey Travolta
Giolito

Eugene Collier
Leppert

Jimmy Ortega
Rondell

Ousaun Elam
Pederson

Ray Lykins
Nixon

Tim Gilbert
McKee

Rick Avery
Cline

Gilbert R. Hill
Todd

Dick Purtan
Detroit Disc Jockey

Fred Asparagus
Bobby

Louis Lombardi
Snake

Lindsey Ginter
Holloway

Michael Bowen
Fletch

David Parry
Taddeo

Stephen McHattie
Steve Fulbright

Al Green
Minister

Hattie Winston
Mrs. Todd

Tracy Melchior
Ticket Booth Girl

Gregory McKinney
Kimbrough

Forry Smith
Rondy

Theresa Randle
Janice

Dan Martin
Cooper

Steven Banks
Spider Ride Operator

George Lucas
Disappointed Man

Christina Venuti
Disappointed Girl

Jonathan Hernandez
Scared Boy

Christy Alvarez
Scared Girl

Yareli Arizmendi
Scared Kids' Mom

Jeannie Epper
Spider Rider

Kurtis Epper
Spider Rider

Bill Taylor
Spider Rider

Neva Sosna
Spider Rider

Nichole McAuley
Spider Rider

Jerra Stewart
Spider Rider

Patty Raya
Spider Rider

Meadow Williams
Spider Rider

Aileen Acain
Waitress

Alan Young
Uncle Dave Thornton

Martha Coolidge
Security Woman

Bronson Pinchot
Serge

Symba
Annihilator Girl

Julie Strain
Annihilator Girl

Heather Elizabeth Parkhurst
Annihilator Girl

George Schaefer
Mike

Joe Dante
Jailer

Curtis Williams
Little Kid

Helen Martin
Grandma

Theodore Borders
Big Kid

Albie Selznick
Technician

Charles Rahi Chun
Technician

Roger E. Reid
Man on Phone

Royce Reid
Feisty Kid

Hector Correa
Man with Video Camera

Elaine Kagan
Sanderson's Secretary

Tino Insana
Burly Cop

John Rubinow
Doctor

Hank McGill
Paramedic

Cherilyn Shea
Girl at Corner

Peter Medak
Man at Corner

Arthur Hiller
Bar Patron

Ray Harryhausen
Bar Patron

Robert B. Sherman
Bar Patron

Eugene Elman
Bartender

Jerry Dunphy
Newscaster

Barbet Schroeder
Man in Porsche

Philip Levien
Serge's Assistant

John Singleton
Fireman

Lisa Allen
Prescott Pig

Julie Dolan
Prescott Pig

Christian Heath
Oki-Doki

Patricia Quinn
Oki-Doki

Sean Spence
Rufus Rabbit

James MacKinnon
Rufus Rabbit

Jennifer Cobb
Meyer Lion

Lynn Walsh
Meyer Lion

Susan Gayle
Kopy Kat

Devin McRae
Kopy Kat

Wendy Harpenau
Liddle Bear

Felicia Wong
Liddle Bear

Marlene Hoffmann
Big Bear

Wanda Welch
Big Bear

Liza Macawili
Floyd Fox

Robin Shelby
Floyd Fox

Dave Myers
Tippy Turtle

Matt Myers
Tippy Turtle

Nick Hermz
Tadross Gorilla

Tim Shuster
Tadross Gorilla

Anthony G. Schmidt
Horvath (uncredited)

Kiante Elam
Car Mechanic (uncredited)

Al Leong
Car Mechanic (uncredited)

Thomas Rosales Jr.
Car Mechanic (uncredited)

Ryal Haakenson
Hotel Doorman (uncredited)

Aliza Washabaugh
OR Nurse (uncredited)

Lynnanne Zager
Beverly Hills Police Station Computer (voice) (uncredited)

Bob Minor
Security Guard in Printing Room (uncredited)

Thomas Rosales Jr.
Car Mechanic