Nick Nolte
Augusto Odone

Susan Sarandon
Michaela Odone

Peter Ustinov
Professor Nikolais

Ann Hearn
Loretta Muscatine

Maduka Steady
Omuori

Aaron Jackson
Francesco Odone

Laura Linney
Young Teacher

Kathleen Wilhoite
Deirdre Murphy

Gerry Bamman
Doctor Judalon

Margo Martindale
Wendy Gimble

James Rebhorn
Ellard Muscatine

Colin Ward
Jake Gimble

LaTanya Richardson Jackson
Nurse Ruth

Jennifer Dundas
Nurse Nancy Jo

William Cameron
Pellerman

Becky Ann Baker
Pellerman's Secretary

Mary Pat Gleason
The Librarian

David Shiner
Clown

Ann Dowd
Pediatrician

Peter MacKenzie
Immunosuppression Doctor

Paul Lazar
Professor Duncan

Joyce Reehling
Columnist

Michael O'Neill
School Psychologist

Richard Cordery
Suddaby's Senior Manager

Angus Barnett
Suddaby's Junior Manager

E. G. Daily
Lorenzo Odone (voice)

Zack O'Malley Greenburg
Lorenzo Odone

Sandy Gore
Murphy Family

Nora Dunfee
Murphy Family

Rocco Sisto
Murphy Family

Amelia Campbell
Murphy Family

Keith Reddin
Murphy Family

Anthony DiLeo Jr.
Conference Parent

Lianne Kressin
Smiling Nurse

Nicolas Petrov
World Bank Executive