Sanaa Lathan
Kenya McQueen

Simon Baker
Brian Kelly

Blair Underwood
Mark Harper

Wendy Raquel Robinson
Cheryl

Taraji P. Henson
Nedra

Golden Brooks
Suzette

Mike Epps
Walter

Donald Faison
Nelson McQueen

Alfre Woodard
Joyce McQueen

Earl Billings
Edmund McQueen

Matt Malloy
Edwin

Katharine Towne
Leah Cahan

Stanley DeSantis
Jack Pino

Marcus Brown
Rashid Mohammed

Fuzzy Fantabulous
DJ Fuzzy Fantabulous (voice)

Henry Simmons
Kyle

Russell Hornsby
Dr. Brockton

Tanisha Harper
Stacy

Michelle Griffin
Kiki

Kimberly Barnett
Luna

Rose Rollins
Lauren

K.C. Clyde
Waiter

Lee Garlington
Mrs. Cahan

Tonita Castro
Maria

Gabriel Tigerman
Darren

Rick Fitts
Emcee

John Ratzenberger
Brian's Father (uncredited)