William Powell
Nick Charles

Myrna Loy
Nora Charles

Keenan Wynn
Clarence "Clinker" Krause

Dean Stockwell
Nick Charles Jr.

Phillip Reed
Tommy Drake

Patricia Morison
Phyllis Talbin

Leon Ames
Mitchell Talbin

Gloria Grahame
Fran Page

Jayne Meadows
Janet Thayar

Ralph Morgan
David Thayar

Bess Flowers
Jessica Thayar

Don Taylor
Buddy Hollis

Warner Anderson
Dr. Monolaw

Bruce Cowling
Phil Brant

Connie Gilchrist
Bertha

Henry Nemo
The Neem

William Bishop
Al Amboy

Marie Windsor
Helen Amboy

Morris Ankrum
Inspector (uncredited)

James Burke
Policeman Callahan (uncredited)

Tom Dugan
Policeman Davis (uncredited)

James Flavin
Policeman Reardon (uncredited)

Esther Howard
Sadie (uncredited)

Clinton Sundberg
Mr. Purdy (uncredited)

Asta Jr.
Asta (uncredited)