Cillian Murphy
John Skillpa / Emma Skillpa

Elliot Page
Maggie

Susan Sarandon
Fanny Crill

Jaimi Paige
Wanda

Josh Lucas
Officer Tom McGonigle

Virginia Newcomb
Doris

Keith Carradine
Ray Crill

Bill Pullman
Edmund French

Graham Beckel
Connor Black

Chris Carlson
Neil

Eden Bodnar
Louise Sternberg

Paul Cram
Kenny

John Paul Gamoke
Mr. Clapp

Joel Thingvall
Guy in Bar (uncredited)

Nathan Christopher
Cal