Jeff Goldblum
Professor Brody

Elizabeth Perkins
Mrs. Brody

Alexander Pollock
Scotty Brody

Miriam Margolyes
Sophie the Castle Maid

Tobey Maguire
Lou the Beagle (voice)

Alec Baldwin
Butch (voice)

Sean Hayes
Mr. Tinkles (voice)

Susan Sarandon
Ivy (voice)

Joe Pantoliano
Peek (voice)

Michael Clarke Duncan
Sam (voice)

Jon Lovitz
Calico (voice)

Charlton Heston
The Mastiff (voice)

Glenn Ficarra
Russian Blue (voice)

Billy West
Ninja Cat #1 (voice)

John Michael Higgins
Ginger Kitten (voice)

Richard Steven Horvitz
Puppy in Barn (voice)

Frank Welker
Buddy (voice)

Frank C. Turner
The Farmer

Lauren K. Robek
Pie Mom (as Kirsten Robek)

Mar Andersons
Guard at Gate

Gillian Barber
Factory Receptionist

Carol Ann Susi
Sophie's Sister

Randi Kaplan
Sophie's Sister

Mary Bogue
Sophie's Sister

Alvin Sanders
Mason Employee

Mark Schooley
Mason Employee

Lou Bollo
Worker

Scott Nicholson
Worker

Trish Schill
Worker

Babe Dolan
Wife Passenger

Reg Glass
Truck Driver (as Reginald Glass)

Charles Andre
Truck Driver

Peggy Logan
Nurse

Alicia Michelle
Jogger

Pamela Perry
Yorkie Dog Owner

Victor Wilson
Doberman Drill Sergeant (voice)

Salome Jens
Collie at HQ (voice)

Danny Mann
Ninja Cat (voice)

Billy West
Ninja Cat (voice)

Paul Pape
Wolf Blitzer (voice)

Myron Natwick
Mr. Mason

Doris Chillcott
Mrs. Calvert