Rick Moranis
Seymour Krelborn

Ellen Greene
Audrey

Vincent Gardenia
Mushnik

Levi Stubbs
Audrey II (voice)

Steve Martin
Orin Scrivello, D.D.S.

Tichina Arnold
Crystal

Michelle Weeks
Ronnette

Tisha Campbell
Chiffon

Jim Belushi
Patrick Martin

John Candy
Wink Wilkinson

Christopher Guest
The First Customer

Bill Murray
Arthur Denton

Stan Jones
Narrator (voice)

Bertice Reading
'Downtown' Old Woman

Ed Wiley
'Downtown' Bum #1

Alan Tilvern
'Downtown' Bum #2

John Scott Martin
'Downtown' Bum #3

Vincent Wong
Chinese Florist

Mak Wilson
Doo-Wop Street Singer

Danny Cunningham
Doo-Wop Street Singer

Danny John-Jules
Doo-Wop Street Singer

Gary Palmer
Doo-Wop Street Singer

Paul Swaby
Doo-Wop Street Singer

Mildred Shay
Second Customer

Melissa Wiltsie
Third Customer

Kevin Scott
Fourth Customer

Barbara Rosenblat
Fifth Customer

Adeen Fogle
Radio Station Assistant

Kelly Huntley
Audrey & Seymour's Kid

Paul Reynolds
Audrey & Seymour's Kid

Miriam Margolyes
Dental Nurse

Abbie Dabner
Boy Patient

Francis Dux
Second Patient

Peter Whitman
Patient on Ceiling

Heather Henson
Girl Patient

Judith Morse
Girl's Mother

Bob Sherman
Agent

Doreen Hermitage
'Life' Magazine Lady

Kerry Shale
Her Assistant

Robert Arden
Network Exec #1

Stephen Hoye
Network Exec #2

Bob Sessions
Network Exec #3

Michael Shannon
Television Reporter

Jill Goldston
Frantic Shopper (uncredited)