Laura Linney
Dr. Karen Ross

Dylan Walsh
Dr. Peter Elliot

Ernie Hudson
Captain Munro Kelly

Tim Curry
Herkermer Homolka

Grant Heslov
Richard

Joe Don Baker
R.B. Travis

Lorene Noh
Amy

Mary Ellen Trainor
Moira

Misty Rosas
Amy the Gorilla

Stuart Pankin
Boyd

Carolyn Seymour
Eleanor Romy

Romy Rosemont
Assistant

James Karen
College President / Elliot's Boss

Bill Pugin
William

Lawrence T. Wrentz
Prof. Arliss Wender

Robert Almodovar
Rudy, TraviCom Security

Kathleen Connors
Sally

Joel Weiss
TraviCom Operator

John Hawkes
Bob Driscoll

Peter Jason
Mr. Janus

Jimmy Buffett
727 Pilot

James Paradise
Transport Worker #1

William John Murphy
Transport Worker #2

Thom Barry
Samahani

Ayo Adejugbe
African Airport Guard

Kevin Grevioux
Roadblock Officer

Karara Muhoro
Roadblock Soldier

Darnell Suttles
Hospital Interrogator

Michael Chinyamurindi
Claude from Mombasa

Willie Amakye
Lead Porter

Malang
Porter

Jay Speed Forney
Porter

Shelton Mack
Porter

David Mungai
Porter

Anthony Mutune
Porter

Sylvester Mwangi
Porter

Les Robinson
Porter

Nelson Shalita
Porter

E.J. Callahan
DC-3 Pilot

Guy Toley
DC-3 Co-Pilot

Jackson Gitonga
Mizumu Tribesman

Andrew Kamuyu
Mizumu Tribesman

Fidel Bateke
Witch Doctor

Shayna Fox
Amy (voice)

Bruce Campbell
Charles Travis

Taylor Nichols
Jeffrey Weems

Adewale Akinnuoye-Agbaje
Kahega

David Anthony
Gorilla

Brian La Rosa
Gorilla

John Munro Cameron
Gorilla (as John Cameron)

John Alexander Lowe
Gorilla

Jay Caputo
Gorilla

Garon Michael
Gorilla

Peter Elliott
Gorilla

David St. Pierre
Gorilla

Eldon Jackson
Gorilla

Philip Tan
Gorilla

Nicholas Kadi
Gorilla

Christopher 'Critter' Antonucci
Gorilla

Loren Cross
Ghost Tribe Member (Uncredited)

Chris Dupre
Tribe Member (Uncredited)

Delroy Lindo
Captain Wanta (Uncredited)

Joe Pantoliano
Eddie Ventro (Uncredited)

Paul Speaks
Scientist (Uncredited)