E. G. Daily
Tommy Pickles (voice)

Nancy Cartwright
Chuckie Finster (voice)

Kath Soucie
Phil DeVille / Lil DeVille / Betty DeVille (voice)

Dionne Quan
Kimi Watanabe-Finster (voice)

Tim Curry
Nigel Thornberry (voice)

Joe Alaskey
Lou Pickles (voice)

Tress MacNeille
Charlotte Pickles (voice)

Michael Bell
Drew Pickles / Charles 'Chaz' Finster, Sr. (voice)

Julia Kato
Kira Watanabe-Finster (voice)

Phil Proctor
Howard DeVille (voice)

Jack Riley
Stuart 'Stu' Pickles (voice)

Tara Strong
Dil Pickles (voice)

Cree Summer
Susie Carmichael (voice)

Cheryl Chase
Angelica Pickels (voice)

Melanie Chartoff
Didi Pickles (voice)

Lacey Chabert
Eliza Thornberry (voice)

Danielle Harris
Debbie Thornberry (voice)

Jodi Carlisle
Marianne Thornberry (voice)

Flea
Donnie Thornberry (voice)

Tom Kane
Darwin (voice)

Bruce Willis
Spike (voice)

Tony Jay
Dr. Lipschitz (voice)

Ethan Phillips
Toa (voice)

Chrissie Hynde
Siri (voice)