Glenn Close
Cruella de Vil

Gérard Depardieu
Jean Pierre Le Pelt

Ioan Gruffudd
Kevin Shepherd

Alice Evans
Chloe Simon

Tim McInnerny
Alonzo

Eric Idle
Waddlesworth (voice)

Ben Crompton
Ewan

Carol MacReady
Agnes

Ian Richardson
Mr. Torte

Jim Carter
Detective Armstrong

Ron Cook
Mr. Button

Timothy West
Judge

David Horovitch
Dr. Pavlov

Dick Brannick
Pavlov's Assistant

Mike Hayley
Constable

Nicholas Hutchison
Reporter

Tim Willcox
ITN Reporter

June Watson
Prison Warden

Tony Bluto
Photocopier Repairman

Tessa Vale
Ticket Seller

John Styles
Punch & Judy Man

Kerry Shale
Le Pelt's Assistant

Thierry Lawson
Le Pelt's Assistant

Hugh Futcher
Brakeman

Charles Simon
Lord Carnivore

Dorothea Phillips
Mrs. Mirthless

Delphine Annaiis
Paris Poodle Lady

Sherwood Ball
Singer (uncredited)

Macéo Bhardwaj
Audience Member (uncredited)

JB Blanc
Police Captain (uncredited)

Ian Boo Khoo
Passenger at Station (uncredited)

Julia Bridgeman
Schoolgirl / Puppy (voice; uncredited)

Greg Bronson
Luncheon Attendee (uncredited)

Martin Brown
TV News Sound Recordist (uncredited)

Kenneth W. Caravan
Cruella Deville Mansion Flunkey (uncredited)

Rene Costa
Paparazzi (uncredited)

Leilani Holmes
Orient Express Passenger (uncredited)

Karen Kennedy
Social Worker / Driver (uncredited)

Suzy Kewer
French Model (uncredited)

David Keyes
Waddlesworth (voice; uncredited)

Jake Lanning
Delivery Man (uncredited)

Jonathan Lucas
Newscaster (voice; uncredited)

Jack Mason
Boy on Climbing Frame (uncredited)

Ann Mills
Fashion Show Editor (uncredited)

Adriana Nima
Dottie (uncredited)

James Payne
Taxi Driver (uncredited)

Brett Reylander
Chef (uncredited)

Nigel Rixon
Bus Driver (uncredited)